Clindamycin + Nicotinamide is a medication combination used to treat acne (pimples) that combines the effects of two different medications. The antibiotic clindamycin acts by entering the skin and eradicating the germs that cause acne. One kind of vitamin B is nicotinamide. When applied topically, it has anti-inflammatory properties that help lessen acne-related swelling, redness, and soreness.
Typical side effects of nicotinamide + clindamycin
Erythema (redness of the skin), dry skin Acne worsening, burning sensation, and itching

Common side effects